Lack of association of antineutrophil cytoplasmic antibodies with joint failure as indicated by joint surgery in rheumatoid arthritis
Identifieur interne : 001E64 ( Main/Exploration ); précédent : 001E63; suivant : 001E65Lack of association of antineutrophil cytoplasmic antibodies with joint failure as indicated by joint surgery in rheumatoid arthritis
Auteurs : Andrew Broadfoot [Australie] ; David Gillis ; Susanna Proudman [Australie]Source :
- APLAR Journal of Rheumatology [ 0219-0494 ] ; 2005-06.
English descriptors
- Teeft :
- Anca, Antineutrophil, Antineutrophil cytoplasmic antibodies, Antinuclear antibody, Aplar journal, Arthritis, Arthritis rheumatism, Arthroplasty, Atypical panca, Autoantibody, Case note review, Cytoplasmic, Disease activity, Disease onset, Health assessment questionnaire, Joint arthroplasty, Joint failure, Joint surgery, Joint surgery group, Laboratory characteristics, Liverpool hospital, Panca, Rheumatoid, Rheumatoid arthritis, Rheumatoid factor, Rheumatology, Study patients, Surgery.
Abstract
Aim: The objective of this study was to investigate a possible association in rheumatoid arthritis (RA) of perinuclear antineutrophil cytoplasmic antibodies (pANCA) and joint failure requiring joint surgery as a well‐defined functional end point. Methods: 188 patients with RA according to the American College of Rheumatology criteria, with a mean duration of disease of 18 years, were enrolled in a cross‐sectional study. Patients were assessed for history of joint surgery, previous/current therapies, function according to the modified Health Assessment Questionnaire (mHAQ), rheumatoid factor (RF) and clinical and laboratory parameters of disease activity. ANCA were detected using indirect immunofluorescence. Results: Overall, 36.7% of patients were pANCA positive (including atypical pANCA) and 35.1% of patients had a history of joint surgery. There was no association between the presence of pANCA and joint surgery. No association was demonstrated between ANCA status and other prognostic markers such as RF, previous or current therapies and disease activity or function. Conclusion: No association between pANCA and joint surgery was demonstrated in this cohort of RA patients.
Url:
DOI: 10.1111/j.1479-8077.2005.00125.x
Affiliations:
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Methods: 188 patients with RA according to the American College of Rheumatology criteria, with a mean duration of disease of 18 years, were enrolled in a cross‐sectional study. Patients were assessed for history of joint surgery, previous/current therapies, function according to the modified Health Assessment Questionnaire (mHAQ), rheumatoid factor (RF) and clinical and laboratory parameters of disease activity. ANCA were detected using indirect immunofluorescence. Results: Overall, 36.7% of patients were pANCA positive (including atypical pANCA) and 35.1% of patients had a history of joint surgery. There was no association between the presence of pANCA and joint surgery. No association was demonstrated between ANCA status and other prognostic markers such as RF, previous or current therapies and disease activity or function. 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